SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Circ Res. 2021 Apr 30;128(9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. Epub 2021 Mar 31.
No abstract available

Keywords: SARS-CoV-2; angiotensin-converting enzyme 2; endothelium.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2 / metabolism*
  • Animals
  • COVID-19 / metabolism
  • COVID-19 / pathology
  • Down-Regulation / physiology*
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • Endothelium, Vascular / virology
  • Mesocricetus
  • Spike Glycoprotein, Coronavirus / metabolism*

Substances

  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Angiotensin-Converting Enzyme 2